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- Shorthorn Cattle Breeders’ Society of South Africa (SCSSA)
- Shumbashaba (Shumbashaba)
- Sibaya Community Trust (SCT)
- Sign Language Education and Development (SLED)
- Simmentaler Cattle Breeders’ Society of South Africa (SCBSSA)
- Simmer Angling Club (SAC)
- Simon`s Town Business Association (STBA)
- Simon’s Town Business Association (STBA)
- Sisters Working in Film and Television (SWIFT)
- Siza Enterprise Development Fund (SIZA)
- Sizwe Taxi Association (STA)
- Skin, Hide and Leather Council (SKALC)
- Skylight Association of South Africa (SASA)
- Slovo Centre of Excellence in action (SCEA)
- Small Business Institute (SBI)
- Small Enterprise Development Agency (SEDA)
- Small Enterprise Development and Finance Agency (SEDFA)
- Small Enterprise Finance Agency (SEFA)
- Small Projects Foundation (SPF)
- Smile Foundation (SF)
- Snow Sports South Africa (SSSA)
- Social Housing Regulatory Authority (SHRA)
- Society for Animals In Distress (SAD)
- Society for Automation, Instrumentation, Mechatronics and Computer Engineering (SAIMC)
- Society for Endocrinology, Metabolism & Diabetes of South Africa (SEMDSA)
- Society for The Prevention of Cruelty To Animals (Tshwane) (SPCA)
- Society of Advocates of Kwazulu-Natal (SAKZN)
- Society of Cosmetic Chemists of South Africa (COSCHEM)
- Society of Hearing Aid Acousticians of South Africa (SHAA)
- Society of Master Mariners, South Africa (SOMMSA)
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