D
- Department: Human Settlements (DHS)
- Department: Independent Police Investigative Directorate (IPID)
- Department: International Relations and Cooperation (DIRCO)
- Department: Justice and Constitutional Development (DOJCD)
- Department: Military Veterans (DMV)
- Department: Mineral Resources and Energy (DMRE)
- Department: Planning, Monitoring and Evaluation (DPME)
- Department: Public Enterprises (DPE)
- Department: Public Service and Administration (DPSA)
- Department: Public Works and Infrastructure (DPWI)
- Department: Science and Innovation (DSI)
- Department: Small Business Development (DSBD)
- Department: Social Development (DSD)
- Department: Sport, Arts and Culture (DSAC)
- Department: State Security Agency (DSSA)
- Department: Tourism (DT)
- Department: Trade, Industry and Competition (DTIC)
- Department: Traditional Affairs (DTA)
- Department: Transport (DOT)
- Department: Water and Sanitation (DWS)
- Department: Women, Youth and Persons with Disabilities (DWYPD)
- Dermatological Society of South Africa (DSSA)
- Design Education Forum of Southern Africa (DEFSA)
- Development Action Group (DAG)
- Development Institute for Training, Support and Education for Labour (DITSELA)
- Dexter Cattle Breeders’ Society of South Africa (DCBSSA)
- Diabetes South Africa (DSA)
- Diamond Dealers Club of South Africa (DDCSA)
- Direct Marketing Association of South Africa (DMASA)
- Direct Selling Association of South Africa (DSA)