- Disability Info South Africa (DISA)
- Disabled People South Africa (DPSA)
- Disaster Management Institute of Southern Africa (DMISA)
- Distance Education Association of Southern Africa (DEASA)
- Doctors for Life (DFL)
- Documentary Filmakers Association (DFA)
- Dohne Merino Breed Society of South Africa (DMBS)
- Dolphin Action and Protection Group (DAPG)
- Domestic Water Heating Manufacturers Cluster of South Africa (DWH-MANCOSA)
- Domino Foundation (DF)
- Doornkop Trap Club (DTC)
- Dormer Sheep Breeders’ Society of South Africa (DSBSSA)
- Dorper Sheep Breeders’ Society of South Africa (DSBSSA)
- Down Syndrome South Africa (DSSA)
- Dr Tebogo Modjadji-Kekana Chamber of Business and Tourism (Tebogo Modjadji-Kekana)
- Drakensberger Breeders’ Society of South Africa (DBSSA)
- Dried Fruit South Africa (DFSA)
- Drybean Producers’ Organisation (DPO)
- Durban Arts Association (DAA)
- Durban Boat Owners Association (DBOA)
- Durban Chamber of Commerce and Industry (DCCI)
- Durban Charter Boat Association (DCBA)
- Durbanville Judo Club (DJC)
- Dystonia Association of South Africa (DASA)
- Early Care Foundation (ECF)
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