S
- Southern Cape Bee Industry Association (SCBIA)
- Soutpansberg Chamber of Business and Tourism (SCBT)
- Soweto Independent Shopkeepers Association ()
- Specialty Coffee Association of Southern Africa (SCASA)
- Spectroscopy Society of SA ()
- Speleological Exploration Club (SEC)
- Spinmasters Angling Society (SAS)
- Sports Science Institute of SA (SSISA)
- Springs Chamber of Commerce & Industry (SCC&I)
- St Dunstan`s Association for SA War-blinded Veterans (SDASWBV)
- St Francis Paddling Club (SFPC)
- St John (SJ)
- Staatsdiens & Aanverwante Werkersvakbond (SAW)
- Standard Transfer Specification Association (STSA)
- State Diamond Trader (SDT)
- Stationery, Home and Office Products Association of Southern Africa (SHOP-SA)
- Statistics Sa (SSA)
- Statistics South Africa (STATSSA)
- Statutory Council for the Squid and Related Fisheries of South Africa (SCSRFSA)
- Statutory Council of the Printing, Newspaper and Packaging Industry of South Africa (SCPNPISA)
- Steel & Engineering Industries Federation of SA (SEIFSA)
- Steel Tube Export Association of South Africa (STEASA)
- Stellenbosch Institute for Advanced Study (STIAS)
- Stellenbosse Sakekamer (SS)
- Stigting Vir Bemagtiging Deur Afrikaans (SBA)
- Stilbaai Tourism Bureau ()
- Strategic Fuel Fund Association (SFF)
- Stroke Aid Society (SAS)
- Stroke Survivors Foundation (SSF)
- Student`s Health and Welfare Centers Organisation (SHAWCO)