S
- Specialty Coffee Association of Southern Africa (SCASA)
- Spectroscopy Society of SA ()
- Speleological Exploration Club (SEC)
- Spinmasters Angling Society (SAS)
- Sport Aerobics and Fitness Federation (SASAFF)
- Sports Science Institute of South Africa (SSISA)
- St Dunstan`s Association for South African War-blinded Veterans (SDASWBV)
- St Dunstan’s Association for South African War-blinded Veterans (SDASWBV)
- St Francis Paddling Club (SFPC)
- Standard Transfer Specification Association (STSA)
- State Diamond Trader (SDT)
- Stationery, Home and Office Products Association of Southern Africa (SHOP-SA)
- Statistics South Africa (STATSSA)
- Statutory Council for the Squid and Related Fisheries of South Africa (SCSRFSA)
- Statutory Council of the Printing, Newspaper and Packaging Industry of South Africa (SCPNPISA)
- Steel & Engineering Industries Federation of Southern Africa (SEIFSA)
- Steel Tube Export Association of South Africa (STEASA)
- Stellenbosch Institute for Advanced Study (STIAS)
- Stigting Vir Bemagtiging Deur Afrikaans (SBA)
- Stilbaai Tourism Bureau (STB)
- Strategic Fuel Fund Association (SFF)
- Stroke Aid Society (SAS)
- Stroke Survivors Foundation (SSF)
- Student’s Health and Welfare Centers Organisation (SHAWCO)
- Suffolk Sheep Breeders’ Society of South Africa (SSBSSA)
- Sugar Milling Research Institute NPC (SMRI)
- Suid-Afrikaanse Akademie Vir Wetenskap & Kuns (SAAWK)
- Sunshine Association (SA)
- Surfing South Africa (SSA)
- Surgical Research Society of South Africa (SRSSA)
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