S
- Steel & Engineering Industries Federation of Southern Africa (SEIFSA)
- Steel Tube Export Association of South Africa (STEASA)
- Stellenbosch Institute for Advanced Study (STIAS)
- Stigting Vir Bemagtiging Deur Afrikaans (SBA)
- Stilbaai Tourism Bureau (STB)
- Strategic Fuel Fund Association (SFF)
- Stroke Aid Society (SAS)
- Stroke Survivors Foundation (SSF)
- Student’s Health and Welfare Centers Organisation (SHAWCO)
- Suffolk Sheep Breeders’ Society of South Africa (SSBSSA)
- Sugar Milling Research Institute NPC (SMRI)
- Suid-Afrikaanse Akademie Vir Wetenskap & Kuns (SAAWK)
- Sunshine Association (SA)
- Surfing South Africa (SSA)
- Surgical Research Society of South Africa (SRSSA)
- Sussex Cattle Breeders’ Society of South Africa (SCBSSA)
- Sustainability Initiative of South Africa (SIZA)
- Sustainable Energy Society of Southern Africa (SESSA)
- Sustainable Energy Fund for Africa (SEFA)
- Sustainable Use Coalition (SUCo)
- Sustento Foundation (SusFon)
- Swimming South Africa (SSA)
- Swiss Rifle Club Cape Town (SRCCT)
- Swiss Rifle Club Johannesburg (SRCJ)
- Swiss Rifle Club Natal (SRCN)
- Working on Fire (SATAS)