S
- Southern African Society for Plant Pathology (SASPP)
- Southern African Society for Trenchless Technology (SASTT)
- Southern African Society of Aquatic Scientists (SASAqS)
- Southern African Vehicle Rental and Leasing Association (SAVRALA)
- Southern African Vinyls Association (SAVA)
- Southern African Wildlife Management Association (SAWMA)
- Southern African Wildlife Management Association (SAWMA)
- Southern African Wood, Laminate and Flooring Association (SAWLFA)
- Southern African Youth in Energy Sector (SAYES)
- Southern Cape Bee Industry Association (SCBIA)
- Soutpansberg Chamber of Business and Tourism (SCBT)
- Soweto Independent Shopkeepers Association ()
- Specialty Coffee Association of Southern Africa (SCASA)
- Spectroscopy Society of SA ()
- Speleological Exploration Club (SEC)
- Spinmasters Angling Society (SAS)
- Sports Science Institute of South Africa (SSISA)
- St Dunstan`s Association for South African War-blinded Veterans (SDASWBV)
- St Dunstan’s Association for South African War-blinded Veterans (SDASWBV)
- St Francis Paddling Club (SFPC)
- Standard Transfer Specification Association (STSA)
- State Diamond Trader (SDT)
- Stationery, Home and Office Products Association of Southern Africa (SHOP-SA)
- Statistics South Africa (STATSSA)
- Statutory Council for the Squid and Related Fisheries of South Africa (SCSRFSA)
- Statutory Council of the Printing, Newspaper and Packaging Industry of South Africa (SCPNPISA)
- Steel & Engineering Industries Federation of Southern Africa (SEIFSA)
- Steel Tube Export Association of South Africa (STEASA)
- Stellenbosch Institute for Advanced Study (STIAS)
- Stigting Vir Bemagtiging Deur Afrikaans (SBA)