I
- Insurance Institute of The Eastern Cape (IIEC)
- Insurance Institute of the Western Cape (IIWC)
- Insurance Sector Education and Training Authority (INSETA)
- Interactive Reality Foundation (IRF)
- Interchange Foundation (IF)
- International Academy of Pathology, South African Division (IAPSA)
- International Association for Impact Assessment South Africa (IAIASA)
- International Education Association of South Africa (IEASA)
- International Fiscal Association South Africa (IFASA)
- International Institute of Construction Arbitrators (IICArb)
- International Life Alignment Association of South Africa (ILAASA)
- International Organization for Migration South Africa (IOMSA)
- International Police Association South Africa (IPASA)
- International Protea Association (IPA)
- International Trade Administration Commission of South Africa (ITAC)
- International Women’s Club of Cape Town (IWCCT)
- Internet Service Providers Association (ISPA)
- InvestSA (ISA)
- Iron & Steel Producers’ Association of South Africa (ISPSA)
- Islamic Medical Association of South Africa (IMASA)
- Islamic Social and Welfare Association (ISWA)
- Italian – South Africa Chamber of Trade & Industries (I-SACT)
- Italian Trade Agency (ITA)
- Kara Heritage Institute (KHI)